Scientific Research

1. Bacillus coagulans (a probiotic)

What it does:

It’s a spore‑forming probiotic that survives stomach acid and reaches the intestines alive. It’s been studied for IBS, diarrhea, and overall gut microbiota balance.

Key Evidence:

  • Hun et al., 2009 – Intestinal Health:
    A randomized controlled trial showed Bacillus coagulans GBI‑30 improved abdominal pain and bloating in IBS patients and improved stool frequency.
    [J Clin Gastroenterol. 2009;43(8):679-83.]
  • Majeed et al., 2016 – Gut microbiota modulation:
    Daily supplementation improved gut microflora composition and reduced GI symptoms in adults.
     [Food Nutr Res. 2016;60:27977.]

Mechanism:

It produces lactic acid, helps digest lactose, and competes with harmful bacteria.

2. Inulin (a prebiotic fiber)

What it does:

A soluble fiber that feeds beneficial gut bacteria, increases short‑chain fatty acids (SCFAs), and improves stool bulk.

Key Evidence:

  • Kolida & Gibson, 2007 – Prebiotic effects:
    Inulin selectively stimulates Bifidobacteria and Lactobacilli in the colon.
    [J Nutr. 2007;137(11 Suppl):2503S-2506S.]
  • Micka et al., 2017 – Gut health improvement:
    Inulin supplementation improved bowel function and increased stool frequency in constipated adults.
     [Nutrients. 2017;9(12):1372.]

Mechanism:

Fermented by gut microbes → produces SCFAs like butyrate → improves gut barrier and motility.

3. Black cumin seed oil (Nigella sativa)

What it does:

Traditionally used for digestive issues; its active compound thymoquinone has anti‑inflammatory and antimicrobial effects that benefit the gut lining.

Key Evidence:

  • Ahmad et al., 2013 – Antimicrobial & anti-inflammatory:
    Nigella sativa oil inhibited pathogenic bacteria like E. coli while sparing beneficial flora.
    [Phytother Res. 2013;27(5):757-762.]
  • Al Jabre et al., 2005 – Digestive benefits:
    Black seed oil was found to reduce gastric discomfort and support mucosal healing in mild gastric irritation models.
    [Saudi Med J. 2005;26(8):1230-1238.]

Mechanism:

Thymoquinone reduces gut inflammation, helps with dyspepsia, and may modulate microbiota indirectly.